Gonadotropin Releasing Hormone Deficiency in Adults


Keeping in mind the multiplication of pregnancy-related issues in today’s world, the necessity to trace the causes of infertility has assumed much relevance. Gonadotrophin-releasing hormone (GnRH) is a typical neurohormonal resource base responsible for laying the foundation of the reproductive hormone cascade. The normal functioning of gonads is based on the rhythmic secretion of GnRH from the hypothalamus. Gonadotrophin-releasing hormone deficiency in adults can be identified by symptoms such as partial or total lack of GnRH-induced luteinizing hormone (LH) pulse. Such deficiency can also be distinguished by tracing the course of GnRH substitution.

Irregularities pertaining to smelling organs are related to Gonadotrophin-releasing hormone deficiency in adults. Medical experts and researchers find it a riveting prospect to address to this issue. Along with olfactory abnormalities, concomitant reproductive malfunctioning is another area of intensive study and research with regards to finding out the causes of gonadotrophin-releasing hormone deficiency in adults.

Eminent Spanish pathologist and clinical expert Maestre de San Juan is widely regarded to be the first person to observe the connection between the impairments of normal testicular growth and and the absence of olfactory bulbs. This deficiency syndrome is referred to as Kallmann Syndrome (KS). In 1944, three US geneticist Kallmann, Barrera and Schoenfeld spotted a genetic basis that provided crucial insight into the probable causes of gonadotrophin-releasing hormone deficiency in adults. Their research gained further momentum in 1954 when de Morsier linked up the symptoms of anosmia and hypogonadism with the impaired development of the frontal part of the brain.

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The decapeptide GnRH is obtained from post-transformational synthesis of tripartite 92-amino acid (AA) pre-pro-GnRH. The starting 23 AA bond is an indicative peptide and the last 56 AA is referred to as GnRH-associated protein (GAP). GnRH is encrypted from a single gene placed on the short arm of chromosome 8. Serum present in GnRH is extremely short-lived. Due to this reason, it is very difficult to extract this substance from the hormone. Pathologists have been able to formulate a number of GnRH analogs that are of great medical importance.

The study of GnRH secretion has never been easy. The structural as well as genetic intricacies of this disorder have been a source to intensive study and research. GnRH is restricted almost entirely to the portal supply of blood in the pituitary.